This systematic literature review examines cryptocurrencies (CCs) and Bitcoin. Because cryptocurrency research has not gained much attention from Information Systems (IS) researchers and needs a more vivid discussion, this review summarizes the main concepts of 42 papers and aligns them to IS Research. Although, cryptocurrency research has not reached IS mainstream yet, there is massive potential for multifaceted research ranging from protocol development to designing alternative digital currency schemes. Cryptocurrencies entail a core digital artifact and present a rich phenomenon based on the intertwining of technological artifacts and social contexts. We argue that cryptocurrencies are an alternative payment method that may replace intermediaries with cryptographic methods and should be embedded in the research areas of SIGeBIZ and SIGSEC. At the end of this literature review, we discuss some open research gaps like new business models based on cryptocurrencies or the influence of culture on cryptocurrencies and Bitcoin.